Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation
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چکیده
منابع مشابه
Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways.
Apoptosis of host cells plays an important role in modulating the pathogenesis of many infectious diseases. It has been reported that Leptospira interrogans, the causal agent of leptospirosis, induces apoptosis in macrophages and hepatocytes. However, the molecular mechanisms responsible for host cell death remained largely unknown. Here we demonstrate that L. interrogans induced apoptosis in a...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2019
ISSN: 1529-2908,1529-2916
DOI: 10.1038/s41590-019-0550-7